A Study of Disitamab Vedotin Combined With Tislelizumab and Chemotherapy Versus Tislelizumab Combined With Chemotherapy in HER2-Low Advanced Gastric or Gastroesophageal Junction Adenocarcinoma

Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18-75
SponsorRemeGen Co., Ltd.

About this trial

The purpose of this study is to evaluate the efficacy and safety of \*\*Disitamab Vedotin combined with Tislelizumab and CAPOX versus Tislelizumab combined with CAPOX\*\* as first-line treatment for patients with HER2-low advanced gastric or gastroesophageal junction adenocarcinoma.

Eligibility criteria

Qualifiers

Voluntarily consent to participate in the study and sign the informed consent form

Expected survival period >12 weeks

ECOG Performance Status 0 or 1

Histologically confirmed unresectable locally advanced, metastatic, or recurrent gastric or gastroesophageal junction adenocarcinoma

Disqualifiers

Presence of central nervous system (CNS) metastasis and/or carcinomatous meningitis

Peripheral neuropathy > Grade 1

Tumor lesions with a tendency to bleed

Uncontrolled diarrhea

Trial design

Treatments tested in this trial

  • Disitamab Vedotin+Tislelizumab+Oxaliplatin+Capecitabine
  • Tislelizumab+Oxaliplatin+Capecitabine

Treatment groups

616 Participants
are divided into 2 treatment groups

Sponsors and collaborators