A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes

Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age10-17
SponsorEli Lilly and Company

About this trial

This study looks at how well a medicine called orforglipron works compared to another medicine called dulaglutide in pediatric participants aged 10 to less than 18 years with type 2 diabetes. The study will also check how safe these medicines are and how the body processes them.

Participation in the study will last about 61 weeks.

Eligibility criteria

Qualifiers

Have type 2 diabetes treated with diet and exercise and metformin and/or basal insulin

Have HbA1c > 6.5% to ≤ 11.0% at screening

Have a body weight ≥50 kilograms (kg) (110 pounds) and a body mass index (BMI) of >85th percentile

Disqualifiers

Have type 1 diabetes

After the type 2 diabetes diagnosis, have a history of diabetic ketoacidosis or hyperosmolar syndrome

Have had at least one episode of severe hypoglycemia and/or at least one episode of hypoglycemic unawareness within the last 6 months before screening

Have a history of pancreatitis or gallbladder disease

Trial design

Treatments tested in this trial

  • Orforglipron
  • Dulaglutide

Treatment groups

170 Participants
are divided into 2 treatment groups

Sponsors and collaborators