Benefits of Inhalation of Hypertonic Saline Solution Prior to Physiotherapy ELTGOL Technique in Bronchiectasis

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorInstitut d'Investigació Biomèdica de Girona Dr. Josep Trueta

About this trial

Bronchiectasis is a chronic bronchial disease in which the usual capacity to remove secretions does not function correctly, causing mucus retention that leads to chronic infection. As with all infections, the use of antibiotics and puss removal are essential treatment elements. Physiotherapeutic techniques are used to assist in the removal of secretions, although these are time-consuming practices that need to be much better studied and which patients often do not continue practicing diligently. A physiotherapeutic technique called (Slow prolonged expiration in lateral decubitus) ELTGOL has been shown to be somewhat effective but as the mucus is viscous in this disorder, it can be difficult to get it to move. It is thought that saline solution inhalations may reduce mucus viscosity and could help to ease expectoration, facilitating the removal of the mucus by the physiotherapeutic technique. This project aims to test this hypothesis, which if true could represent an advance in the treatment of this severely debilitating disease.

Eligibility criteria

Qualifiers

Adult patients with bronchiectasis confirmed by high resolution computed tomography

No exacerbations in the previous month

Chronic mucopurulent and purulent sputum

≥10ml daily expectoration

Disqualifiers

Current smokers or a smoking history of ≥20 p-y

Asthma, allergic bronchopulmonary aspergillosis or Cystic Fibrosis

Pregnant or lactating women

Following mucoactive treatment in the previous month

Trial design

Treatments tested in this trial

  • Hypertonic saline
  • Isotonic saline
  • ELTGOL

Treatment groups

57 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta

Lead sponsor

University Hospital of Girona Dr. Josep Trueta

Collaborator

Germans Trias i Pujol Hospital

Collaborator