Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexFemale
Age18+
SponsorCentre Hospitalier Intercommunal Creteil

About this trial

A randomized clinical trial to assess the efficiency of acetylsalicylic acid (aspirin) 150 mg/day started before 20 weeks of gestation in the prevention on maternal and fœtal complications in pregnant women with chronic hypertension.

Eligibility criteria

Qualifiers

Pregnant patient between 10 and 19 weeks of gestation + 6 days

Chronic hypertension, whether treated or not, know before pregnancy or diagnosed before randomization

Singleton pregnancy

Signed the written informed consent

Disqualifiers

---Medical history requiring anticoagulation (antiphospholipid syndrome, deep vein thromboembolic disease, pulmonary embolism, atherothrombosis, patient with mechanical heart valves),

Patient receiving aspirin for another indication outside pregnancy,

Patient with significant proteinuria (> 300mg/24 hours or a proteinuria/creatininuria ratio ≥ 30mg/mmol),

Active bleeding,

Trial design

Treatments tested in this trial

  • Aspirin 150 mg
  • Placebo

Treatment groups

500 Participants
are divided into 2 treatment groups