Cilostazol for Preventing Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage

Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18-80
SponsorBeijing Tiantan Hospital

About this trial

The investigators propose to conduct a multicenter randomized trial to test whether cilostazol reduces the incidence of delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) and improves patients' neurological prognosis, while assessing its safety.

Eligibility criteria

Qualifiers

Aged 18-80 years.

Diagnosed with subarachnoid hemorrhage (SAH) by computed tomography (CT) scan, and the responsible aneurysm is clearly identified by computed tomography angiography (CTA) or digital subtraction angiography (DSA).

Received aneurysm coil embolization or craniotomy clipping within 72 hours of symptom onset.

Hunt-Hess grade II-IV.

Disqualifiers

Multiple aneurysms (>1aneurysms confirmed by CTA/DSA)

Modified Rankin Scale (mRS) score ≥ 3 before onset

Allergy to cilostazol

Severe heart failure(New York Heart Association (NYHA) Functional Classification Grade III or IV)

Trial design

Treatments tested in this trial

  • Cilostazol 100 mg BID
  • placebo

Treatment groups

316 Participants
are divided into 2 treatment groups

Sponsors and collaborators