Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

ConditionTraumatic Brain Injury

Trial statusRecruiting

Trial phasePhase 3

Trial typeInterventional

Biological sexAll

Age50+

SponsorLondon School of Hygiene and Tropical Medicine

About this trial

Tranexamic acid (TXA) reduces head injury deaths. The CRASH-4 trial aims to assess the effects of early intramuscular TXA on intracranial haemorrhage, disability, death, and dementia in older adults with symptomatic mild head injury

Eligibility criteria

Qualifiers

50 years or older (actual or estimated)

History or evidence of head injury (e.g. laceration, bruise, swelling or pain in head or face)

GCS ≥ 13

has or had any impaired consciousness (loss of consciousness, amnesia, or confusion)

Disqualifiers

None

Trial design

Treatments tested in this trial

Tranexamic Acid 500 MG

Treatment groups

5,000 Participants

are divided into 2 treatment groups

Sponsors and collaborators

London School of Hygiene and Tropical Medicine

Lead sponsor

Source ClinicalTrials.gov