Comparative Study of Nutraceuticals vs. Conventional Prophylactic Therapy in the Management of Migraine

Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorFayoum University

About this trial

Migraine is a common disabling neurological condition that significantly affects quality of life. While traditional prophylactic treatments (e.g., beta-blockers, antiepileptics) are effective, they may be associated with side effects leading to poor adherence. Recent evidence suggests that nutraceuticals like magnesium, riboflavin, and coenzyme Q10 may provide a safer alternative. This study aims to compare the efficacy and tolerability of these two approaches.

Eligibility criteria

Qualifiers

Adults aged 18-60 years

- Diagnosed with episodic migraine (ICHD-3 criteria)

- ≥4 migraine attacks/month for the past 3 months

- Willing to provide informed consent

Disqualifiers

• - Chronic migraine (>15 headache days/month)

- Use of other prophylactic treatments in past month

- History of secondary headaches

- Pregnancy or breastfeeding

Trial design

Treatments tested in this trial

  • Propranolol 80 mg
  • Magnesium 400Mg

Treatment groups

100 Participants
are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators