The purpose of this study is to compare the effect of prasugrel plus low-dose aspirin versus high dose aspirin alone (300mg) and versus low dose aspirin alone (75 mg) in patients with chronic coronary disease undergoing coronary artery bypass grafting.
Age >18 years
Primary isolated CABG patients with stable coronary artery disease (chronic coronary syndrome) planned for at least 2 grafts. Coronary artery disease will be defined as a stenosis ≥ 70% based on coronary angiography, a FFR value ≤ 0.80 or iFr value ≤0.89; a left main diameter stenosis ≥ 50%, left main IVUS MLA value ≤ 6 mm2, or equivalent OCT measurements will also be considered.
Ability to comply with all study procedures and follow-up procedures
Signed Informed Consent to participate in the study.
Cardiogenic shock
Patients with recent acute coronary syndrome (ACS) (<12 months)
Single vessel CABG
Patients with preoperative atrial fibrillation
Dolnośląskie Centrum Chorób Serca im.prof. Zbigniewa Religi MEDINET Sp. z o.o.
Lead sponsor
Medical Research Agency, Poland
Collaborator