Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases
ConditionSpinal Metastases
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorStanford University
About this trial
The goal of this study is to determine whether fractionated Stereotactic radiosurgery (SRS) for spine metastases is associated with improved local tumor control compared to single-fraction SRS. Patients will be randomized to treatment with spine SRS using either 22 Gy in 1 fraction or 28 Gy in 2 fractions.
Eligibility criteria
Qualifiers
Histologically, cytologically, or radiographically confirmed diagnosis of metastatic cancer Age ≥ 18 years
Patients who have cervical, thoracic, or lumbar spine metastasis that need treatment.
Patients will have 1 to 3 separate spinal sites that require treatment.
Each spinal site to be treated on trial will span 1-2 contiguous vertebral levels
Disqualifiers
Prior or planned radiation off study within or overlapping with study treatment site
Inability to have either an MRI or a CT scan. Patients with pacemaker will be allowed to undergo CT instead of MRI
Pediatric patients (age <18 years old), pregnant women, and nursing patients will be excluded
Histology's of myeloma or lymphoma
Trial design
Treatments tested in this trial
- Single-fraction spine SRS
- Multi-fraction spine SRS
Treatment groups
274 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov