Comparison of Curcumin and Intralesional Steroids in Oral Submucous Fibrosis

Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorServices Institute of Medical Sciences, Pakistan

About this trial

The goal of this clinical trial is to learn if Curcumin is better than Intralesional Steroid Injection for the treatment of oral submucous fibrosis. The main question it aims to answers are:

1. If Curcumin is more effective to improve burning sensation as compared to Intralesional steroid. 2. Does Curcumin treatment results in better mouth opening versus Intralesional steroid. 3. Can Curcumin helps to improve tongue protrusion as compared to Intralesional steroids.

Participants will be:

* Assessed for one month, two month and three month. * Burning Sensation will be assessed with visual analogue scale (VAS). * Mouth Opening will be measured in mm with ruler. * Tongue Protrusion will be assessed with the visual analogue scale (VAS).

Eligibility criteria

Qualifiers

Patients diagnosed with Oral submucous fibrosis in accordance with operational definition.

Male & Female

Disqualifiers

Patient unable to quit the habit of gutkha, tobacco & betel nut chewing

Patient With uncontrolled diabetes

Patient with chronic kidney disease

Pregnant female

Trial design

Treatments tested in this trial

  • Curcumin (Turmeric)
  • Intralesional Steroid Injection

Treatment groups

70 Participants
are divided into 2 treatment groups