Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections
ConditionSurgical Site Infection
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18-80
SponsorLoma Linda University
About this trial
This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to normal saline in male and female patients between the ages of 18 and 80 years old undergoing emergency laparotomies with Centers for Disease Control (CDC) class 2 and 3 wounds.
Eligibility criteria
Qualifiers
18 to 80 years of age
undergoing an exploratory laparotomy for Centers for Disease Control class II and III wounds
Disqualifiers
Pregnancy
Preoperative abdominal wall skin/soft tissue infection
Iodine allergy
Patients unlikely to survive beyond 30 days
Trial design
Treatments tested in this trial
- Povidone-Iodine
- Normal Saline
Treatment groups
1,100 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov