About this trial
This study investigates whether direct transfer to an emergency stroke unit equipped with NeuAngio-CT reduces time to endovascular reperfusion in patients with acute ischemic stroke and suspected intracranial large-vessel occlusion.Those aged 18-60 years with acute ischemic stroke who are eligible for endovascular thrombectomy within 24 hours of symptom onset will be enrolled. Participants will be randomly assigned to one of two groups. In the intervention group, participants will undergo femoral or radial artery puncture, followed by intracranial and cervical CT angiography with intra-arterial contrast injection (iacCTA) performed using the sliding-rail NeuAngio-CT, and subsequent thrombectomy guided by fused CTA-DSA images. In the control group, participants will receive intracranial and cervical CT angiography with intra-venous contrast injection and the thrombectomy will guided by standard DSA imaging without use of the sliding-rail CT. The primary endpoint is puncture-to-successful-reperfusion time (PRT); if successful reperfusion is not achieved, the end-of-procedure time will be used.
Eligibility criteria
Qualifiers
Age 18-60 years;
Clinical diagnosis of acute ischemic stroke eligible for immediate endovascular treatment;
Time from symptom onset or last known well ≤ 24 hours;
Intravenous intracranial and cervical CT angiography completed;
Disqualifiers
Known contrast agent allergy;
Renal insufficiency with GFR (glomerular filtration rate) < 45 mL/min/1.73 m²;
History of kidney transplantation;
Concomitant diabetes mellitus with current use of metformin;
Trial design
Treatments tested in this trial
- Direct Angio Suite Acute Stroke Intervention With CT/DSA Hybrid Emergency Stroke Unit
- Conventional Thrombectomy