DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 Infection

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorANRS, Emerging Infectious Diseases

About this trial

Phase III trial evaluating doravirine as an alternative to dolutegravir in treatment naïve people living with HIV-1 infection.

Eligibility criteria

Qualifiers

Be at least 18 years of age on the day of signing the informed consent.

Be HIV-1 positive as determined according to national testing strategies

Have a plasma HIV-1 RNA ≥1000 copies/mL within 30 days prior to the randomization,

Have HIV treatment indication based on physician assessment according to local treatment guidelines

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Doravirine + tenofovir DF + lamivudine
  • Dolutegravir + tenofovir DF + lamivudine or emtricitabine

Treatment groups

610 Participants
are divided into 2 treatment groups

Sponsors and collaborators

ANRS, Emerging Infectious Diseases

Lead sponsor

MSD France

Collaborator

European and Developing Countries Clinical Trials Partnership (EDCTP)

Collaborator