Early Amiodarone in Shockable Cardiac Arrest

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorOregon Health and Science University

About this trial

The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute cycle earlier than current guidelines (during the same cycle as the initial dose of epinephrine) improves the time to amiodarone delivery in those with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or ventricular tachycardia compared to usual care.

Eligibility criteria

Qualifiers

Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest

Initial rhythm on EMS rhythm assessment of ventricular fibrillation or ventricular tachycardia

Recurrence or persistence of ventricular fibrillation or ventricular tachycardia after one defibrillation attempt

Disqualifiers

Known allergy to amiodarone

EMS-assessed contraindication to amiodarone

Pre-existing "do-not-attempt-resuscitation" orders

Inter-facility transportations

Trial design

Treatments tested in this trial

  • Amiodarone Hydrochloride Injection
  • Usual Care Protocol

Treatment groups

585 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Oregon Health and Science University

Lead sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator