This study is a multicenter RCT to compare 3-year overall survival(OS) rate, progression free survival(PFS),local progression free survival(LPFS),regional progression free survival(RPFS),distant metastasis free survival(DMFS), and toxicities of endonasal endoscopic surgery versus IMRT.
Diagnosed of recurrent nasopharyngeal carcinoma by pathology or imaging study;
Stage T1 or T2 according to AJCC 8th edition ;
Aged 18 to 70 years;
Without metastasis;
Refuse to sign inform consent;
Radiation encephalopathy or leptomeningeal disease (LMD);
History of radioactive particle planting;
Have uncontrolled intercurrent illnesses which will interfere with the ability to undergo therapy;
Eye & ENT Hospital of Fudan University
Lead sponsor
Chinese Academy of Medical Sciences
Collaborator
Shanghai Municipal Science and Technology Commission
Collaborator