Effect of GH on the Blastocyst Euploid Rate in AMA Patients
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexFemale
Age38+
SponsorShangHai Ji Ai Genetics & IVF Institute
About this trial
This randomized trial aims to compare the euploid rate of blastocysts in AMA patients undergoing PGT-A (preimplantation genetic testing for aneuploidy) with or without growth hormone supplement.
Infertile patients ≥38 years old will be recruited for study after informed consent if they fulfill the inclusion criteria and do not have the exclusion criteria. Eligible women will be randomised into one of the two groups:
Treatment group: Women will receive growth hormone (GH) supplement before and during antagonist protocol for ovarian stimulation.
Control group: Women will receive antagonist protocol for ovarian stimulation. The primary outcome is the euploidy rate of blastocysts.
Eligibility criteria
Qualifiers
Age ≥38; intended to undergo PGT-A
BMI in the normal range (18.50-24.0kg/m2)
Normal semen analysis for the male partner
Disqualifiers
Endometriosis grade 3 or higher, untreat hydrosalpinx
Women with a uterine cavity abnormality, such as a uterine congenital malformation (uterus uni-cornate, bicornate, or duplex); untreated uterine septum, adenomyosis, submucous myoma, or endo-metrial polyp(s)
Women who are indicated and planned to undergo PGT-SR (Preimplantation genetic testing for structural rearrangement) or PGT-M (Preimplantation genetic testing for monogenic disorder), for example, parental abnormal karyo-type or diagnosed with monogenic disease
History of endocrine disorder, autoimmune diseases or diagnosed thrombophilia
Trial design
Treatments tested in this trial
- Growth Hormone
- GnRH antagonist
Treatment groups
400 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov