The purpose of this study is to demonstrate the efficacy of early continuous intravenous infusion of hypertonic saline solution (HSS) to improve survival and independence in daily life activities (at 6 months) of patients with traumatic brain injury at high risk of intracranial hypertension.
Patient admitted to intensive care unit
Traumatic brain injury with Glasgow Coma Scale ≤ 12
Intracranial pressure (ICP) monitoring based on the attending physician's clinical judgment, in accordance with guidelines or clinical/radiological signs considered at risk of intracranial hypertension
Inclusion during the first 12 hours after Intracranial pressure monitoring placement
Glasgow Coma Scale (score = 3) and persistent abnormal pupillaryreactivity despite urgent therapy
Associated cervical spinal cord injury
Imminent death and do-not-resuscitate orders
Coma secondary to cardiac arrest