Efficacy of Intravenous Dexamethasone in Prolonging the Duration of Spinal Anesthesia With Chloroprocaine in Knee Arthroscopy

Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorCMC Ambroise Paré

About this trial

Chloroprocaine is a short-acting local anesthetic that allows rapid recovery and early ambulation but is currently recommended for procedures lasting 40 minutes or less.

Dexamethasone is commonly used during anesthesia for the prevention of postoperative nausea and vomiting and has also been shown to prolong the duration of analgesia and sensory block after regional anesthesia.

Dexamethasone may therefore extend the duration of chloroprocaine spinal anesthesia, potentially allowing its use for longer surgical procedures while maintaining the benefits of rapid postoperative recovery.

This study aims to evaluate whether intravenous dexamethasone can prolong the effects of spinal anesthesia performed with chloroprocaine in adults undergoing knee arthroscopy.

Eligibility criteria

Qualifiers

Undergoing knee arthroscopy lasting ≤ 40 minutes requiring spinal anesthesia (diagnostic arthroscopy or meniscal surgery),

Signed written informed consent form,

Affiliation to a social security system,

Negative pregnancy test on the day of procedure for non-menopausal patients.

Disqualifiers

Contraindications to spinal anesthesia with intrathecal chloroprocaine

History of diabetes,

Pre-existing peripheral neuropathy,

American Society of Anesthesiologists (ASA) physical status IV,

Trial design

Treatments tested in this trial

  • Sodium Chloride 0.9%
  • Dexamethasone
  • Chloroprocaine Injection [Clorotekal]

Treatment groups

60 Participants
are divided into 2 treatment groups

Sponsors and collaborators