Evaluating the Safety and Efficacy of Ondansetron in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18-65
SponsorTanta University

About this trial

Endoscopic retrograde cholangiopancreatography (ERCP (, a key tool that is used in diagnosis and treatment of pancreato-biliary diseases. Post-ERCP pancreatitis (PEP) is the most common and serious complication that can occur following this procedure and can lead to significant morbidity and mortality. A variety of patient-related and procedure-related factors have been associated with higher rates of PEP.

Eligibility criteria

Qualifiers

Age more than 18 years old.

Gender: Males and Females

Patients with suitable indications for ERCP due to suspected pancreato-biliary disorders.

Blood amylase and lipase levels before ERCP are within the normal limits.

Disqualifiers

Age of less than18 years.

Uncontrolled diabetes mellitus (DM)

Severe bleeding tendency

Impaired renal function (serum creatinine > 2 mg/dL), (creatinine clearance <30 ml/min)

Trial design

Treatments tested in this trial

  • Placebo
  • Ondansetron

Treatment groups

44 Participants
are divided into 2 treatment groups

Sponsors and collaborators