The purpose of this phase III clinical trial, is to evaluate the efficacy and safety of concomitant chemo-radiotherapy with Cisplatin vs Gemcitabine as the first line of treatment in patients with locally advanced cervical cancer, with comorbidities and preserved renal function.
Singed informed consent.
Women with Age ≥ 18 years.
-In women of childbearing age it should be documented: a) negative pregnancy test in serum at the beginning of the study (14 days before the start of QT-RT); b) Accept the use of some method of contraception approved by your attending physician during the study and 12 weeks after the treatment has ended.
-In postmenopausal women (surgical or natural menopause) at least one of the following parameters must be met for inclusion.
Patients with a second neoplasm.
Pregnant or lactating patients.
Patients with small cell and / or neuroendocrine CaCu.
Patients with impaired renal function with a GFR <or equal to 60ml / min calculated by the CKD-EPI formula