Evaluation of RAY1225 in Adult Participants Who Have Obesity or Are Overweight
ConditionObesity
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorGuangdong Raynovent Biotech Co., Ltd
About this trial
The primary objective of this study is to demonstrate that RAY1225 is superior to placebo for percent change in body weight.
Eligibility criteria
Qualifiers
Age ≥ 18 years.
Body mass index ≥ 28 kg/m2 or ≥24kg/m² to <28 kg/m2 with at least 1 of the following weight-related comorbidities: a) Systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg, or the use of at least one antihypertensive medication to maintain normal blood pressure;b) Fasting triglycerides (TG) ≥1.70 mmol/L, fasting low-density lipoprotein cholesterol (LDL-C) ≥4.1 mmol/L, fasting high-density lipoprotein cholesterol (HDL-C) <1.04 mmol/L, or the need for at least one lipid-lowering treatment to maintain normal lipid levels; c) Obstructive sleep apnea syndrome; d) Fatty liver; e) Cardiovascular disease; e) Polycystic ovary syndrome.
History of at least 1 self-reported unsuccessful attempt at weight loss by diet and exercise.
Disqualifiers
Obesity known to be caused by monogenic mutations, other diseases, or medications.
Family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2.
A history of moderate to severe depression at any time in the past or a score of ≥15 on the PHQ-9 questionnaire at screening; a history of bipolar disorder, schizophrenia, or other severe psychiatric disorders.
A history of organ transplantation (excluding corneal transplant), or being currently prepared to undergo organ transplantation.
Trial design
Treatments tested in this trial
- RAY1225
- Placebo
Treatment groups
640 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov