This open-label, randomized multicenter trial aims at clarifying the standard of care of patients with non-convulsive status epilepticus not responding to treatment with benzodiazepines and at least one high-dose intra venous anti-seizure medication.
Adult patients (older than 18 years) with EEG-verified NCSE, according to the Salzburg criteria, who have not responded to appropriate treatment with benzodiazepines and at least one 2nd line i.v. anti-seizure medication according to the current Danish national neurological treatment guidelines (Levetiracetam, Fosfenytoin or Valproate).
patients with epilepticus status due to acute neuroinfection (e.g. bacterial meningitis or viral encephalitis)
acute traumatic or spontaneous intracranial hemorrhage
suspicion of cerebral anoxia / hypoxia / hypoglycemia / epileptic encephalopathy
contraindications to anti-seizure medication defined in the protocol
University of Southern Denmark
Lead sponsor
Aarhus University Hospital
Collaborator
University Hospital of Zealand
Collaborator
Copenhagen University Hospital, Denmark
Collaborator