About this trial
In view of the positive results of the numerous studies conducted on forced diuresis after extra-corporeal lithotripsy, the investigators chose to evaluate forced diuresis by injection of Furosemide associated with intravenous hydration, which has never before been the subject of a specific analysis.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients ≥ 18 years old and < 80 years old
With the need to perform a flexible ureteroscopy with destruction of the kidney stones with laser
Participants covered by or entitled to social security
Written informed consent obtained from the participant
Disqualifiers
Persons covered by articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, minors, and persons subject to a legal protection measure: guardianship or trusteeship)
Hyper-sensitivity to the active substance or one of the excipients
Hyper-sensitivity to Sulfonamide
Renal failure with oligo-anuria refractory to Furosemide
Trial design
Parallel
Treatments tested in this trial
Furosemide 40 mg
DrugInjection of 40 mg of Furosemide during 10 minutes after the end of the flexible ureteroscopy for destruction of kidney stones with laser.
Treatment groups
Trial outcomes
Primary outcomes
Rate of stone free patients
Rate of stone-free patients 3 months after a flexible ureteroscopy for renal stone laser destruction, evaluated on the low dose abdomino-pelvic CT-Scan. A centralized review of the images will be performed by two specialized radiologists, in a blind and crossed way to allow a homogenization of the results
Secondary outcomes
Rate of urinary infection
Rate of post-operative urinary tract infection will be assessed within 30 days after surgery on the combination of: * Fever higher than 38.5°C and/or, * Chills and/or, * Clinical symptoms (supra-pubic pain, dysuria, pollakiuria, urgency, urinary burning, back pain radiating to the genitals, hematuria) and/or * Positive urine culture with a significant bacteriuria threshold defined as bacteriuria ≥10\^5 UFC/mL with one or two bacterial species.
Pain in a scale
Post-operative pain will be assessed on numerical pain scale in the recovery room, in the service and at the discharge. Pain scale is from 0 (no pain) to 10 (as bad as it could be nothing else matters)
Opioid consumption
The use of opioids will be reported
Number of participants with adverse events
Number of participants with Furosemide adverse events
Sponsors and contacts
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