Impact of Low Dose Epinephrine in the Management of Out-of-hospital Cardiac Arrest on Neurological Outcome
Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentral Hospital, Nancy, France
About this trial
This study will test whether a lower dose of epinephrine (0.5 mg) given during emergency treatment for out-of-hospital cardiac arrest helps more patients survive with good brain function, compared to the standard dose (1 mg). Adults who experience cardiac arrest outside the hospital and are treated by emergency medical teams will be randomly assigned to receive either the low dose or the standard dose of epinephrine. The study will compare survival and neurological outcomes between the two groups over 28 days.
Eligibility criteria
Qualifiers
None
Disqualifiers
Non-medical Out-of-hospital cardiac arrest (traumatic, drownings, electrocution, asphyxia, overdose, unknown cause).
Out-of-hospital cardiac arrest without advanced life support (Do Not Attempt Resuscitation order, body finding, the decision not to attempt advanced life support is at the physician's discretion).
Pregnant women, birthing or breastfeeding mothers
Adults under legal protection measure (such as guardianship, conservatorship)
Trial design
Treatments tested in this trial
- Epinephrine 0.5 mg intravenous bolus
- Epinephrine 1 mg intravenous bolus
Treatment groups
4,336 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov