Intra-wound Vancomycin Powder for Prevention of Surgical Site Infection Following Spinal Surgery
ConditionInfection
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18-90
SponsorRabin Medical Center
About this trial
Cefazolin is given routinely pre and intraoperatively for patients undergoing spinal surgery to reduce the rate of infection. Intra-wound admission of Vancomycin powder has been suggested to reduce wound infection rates. Therefore, this study aims to compare the rate of wound-related complications between patients receiving standard treatment compared to patients receiving an addition of topical Vancomycin and to identify the optimal Vancomycin dosage. All groups will receive the recommended regimen of routine IV antibiotic prophylaxis.
Eligibility criteria
Qualifiers
Patients undergoing posterior spinal fusion operation at the neurosurgery department at the Rabin Medical Center
Ability to understand and sign written informed consent by the patient or legal guardian
Disqualifiers
Preoperative ongoing infectious disease present as judged by the primary surgeon (based on lab results and clinical assessment)
Receiving ongoing treatment of antibiotics for other infections
Sensitivity or allergy to vancomycin or cefazolin
Previous spine surgery at the index level within the last 90 days
Trial design
Treatments tested in this trial
- Vancomycin
Treatment groups
363 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov