Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexMale
Age18-80
SponsorIndiana University

About this trial

This randomization study is to compare both intrathecal morphine and intravenous methadone, which are both standard of care, for pain management in patients undergoing retroperitoneal lymph node dissections for primary testicular cancer. Investigators plan to compare their analgesic effectiveness at different postoperative time intervals.

Eligibility criteria

Qualifiers

Patients undergoing a virgin (chemotherapy has not been used) or post- chemotherapy retroperitoneal lymph node dissection for primary testicular cancer at IU Health AAHC

ASA Class 1, 2, 3

Age 18 to 80 years; Male

BMI less than 50kg/m2

Disqualifiers

Any contraindication for neuraxial analgesia

Patient on home methadone at any dose

Any physical, mental or medical conditions which, in the opinion of the investigators, may confound quantifying postoperative pain resulting from surgery.

Known true allergy to the study medications (morphine, bupivacaine, acetaminophen, methadone)

Trial design

Treatments tested in this trial

  • Inrathecal Morphine
  • Intravenous Methadone

Treatment groups

142 Participants
are divided into 2 treatment groups

Sponsors and collaborators