This study evaluates the use of a lower INR target (1.5 to 2.5) in patients with a mechanical bileaflet heart valve in the aortic position. This study will inform physicians about whether a lower INR target will decrease the risk of bleeding or increase the risk of blood clot formation and stroke. These results have the potential to reduce the burden of bleeding in patients with a mechanical heart valve who require lifelong warfarin (Coumadin) treatment.
Age is 18 or older at the time of enrolment
Have had a bileaflet mechanical heart valve implant in the aortic position 3 or more months ago
Written informed consent from either the patient or substitute decision maker
Has a second implanted mechanical valve (any position)
Lower boundary of planned INR range is less than 2.0
Pregnant or expecting to become pregnant during the study follow-up
Population Health Research Institute
Lead sponsor
Hamilton Health Sciences Corporation
Collaborator