Modulating Inhibitory Control Networks in Gambling Disorder With Theta Burst Stimulation
ConditionGambling Disorder
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18-65
SponsorCNS Onlus
About this trial
In this project the investigators propose a randomized double-blind placebo-controlled design in which 40 patients with GD will receive active or sham cTBS to the pre-SMA for 2 weeks. The investigators will combine TMS, multimodal structural and functional MRI and behavioral measures in order to identify circuit-level mechanisms of action and therapeutic targets (connectivity changes that explain clinical improvement) and assess the efficacy of TMS in modulating inhibitory control and symptom severity in this population.
Eligibility criteria
Qualifiers
DSM-5 diagnosis of Gambling Disorder
Age between 18 and 65 years
Disqualifiers
any additional current psychiatric comorbidity, except for nicotine addiction;
a lifetime DSM-5 diagnosis of schizophrenia or other psychotic syndromes, substance dependence or substance abuse, including alcohol, bipolar I or II disorder, mental disorder due to a general medical condition;
serious suicide risk;
illness duration less than two years;
Trial design
Treatments tested in this trial
- Transcranial Magnetic stimulation
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov