Multi-Center Clean Air Randomized Controlled Trial in COPD
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age40+
SponsorJHSPH Center for Clinical Trials
About this trial
This is a multi-center randomized, sham-controlled clinical trial to determine the effectiveness of an air cleaner intervention aimed at improving indoor air quality on reducing COPD exacerbation risk and improving quality of life, functional status, rescue medication use.
Eligibility criteria
Qualifiers
Age ≥ 40 years.
Self-report of physician diagnosis of COPD.
Spirometry confirmed airway obstruction (post-bronchodilator spirometry of forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) < 0.7) as defined by the Global Initiative for Obstructive Lung Disease (GOLD) criteria (6, 11)
Tobacco exposure ≥ 10 pack-years. This refers to regular cigarette tobacco consumption.
Disqualifiers
Living in a location other than home (e.g., long-term care facility, nursing home)
Other chronic lung diseases, except asthma
Condition with less than a year of life expectancy (e.g., metastatic cancer) or in hospice
Spends >2 months per year in location other than home; or plans to change residence in the next 12 months
Trial design
Treatments tested in this trial
- Air cleaner
- Sham air cleaner
Treatment groups
770 Participants
are divided into 2 treatment groupsSponsors and collaborators
JHSPH Center for Clinical Trials
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Source ClinicalTrials.gov