To compare the effectiveness and toxicity of nedaplatin versus cisplatin in induction chemotherapy combined with concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma.
Patients with newly histologically confirmed non-keratinizing nasopharyngeal carcinoma, including WHO II or III
Original clinical staged as III-IVa (except T3-4N0) according to the 8th edition American Joint Committee on Cancer staging system
No evidence of distant metastasis (M0)
Age between 18-65
Histologically confirmed keratinizing nasopharyngeal carcinoma (WHO I)
Age >65 or < 18 years
Treatment with palliative intent
Prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer