The goal of this randomized clinical trials is to ascertain the safety and efficacy of immediate reimplantation of cardiac electronic implantable devices in patients with endocarditis and device-infections, compared to standard care, i.e. reimplantation at a later procedure date.
The primary outcome is the occurence of the composite primary endpoint within 6 months of randomization consisting of
* Death * Symptomatic embolism (systemic arterial embolism or pulmonary embolism) * Bacteremia og pocket-infection * Removal of a CIED due to new infection
Culture positive or negative infection of a CIED acording to PI
Indication for removal of device
Clinical indication of device removal of existing device (concurrent left-sided IE is not a contraindication).
Indication for reimplantation of new device
Immunoincompetence (active chemotherapy or prednisone treatment > 20mg/day
Device-infection within last 6 months (relaps)
Septic shock
Stabilization criteria not fulfilled after 10 days of suficient antibiotic treatment