Non-steroidal Anti-inflammatory in Cardiac Surgery

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire, Amiens

About this trial

Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.

Eligibility criteria

Qualifiers

scheduled for cardiac surgery (aortic valve replacement, coronary artery bypass graft, mitral valve repair or replacement, intracardiac tumor, aortic root repair)

under cardiopulmonary bypass

Affiliation to the French national healthcare system

Written consent obtained

Disqualifiers

age<18

weight<50 kg

chronic use of NSAID

mini-invasive surgery

Trial design

Treatments tested in this trial

  • pain management
  • ketoprofen
  • PLacebo

Treatment groups

238 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Centre Hospitalier Universitaire, Amiens

Lead sponsor

University Hospital, Rouen

Collaborator

University Hospital, Lille

Collaborator

University Hospital, Caen

Collaborator