About this trial
Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.
Eligibility criteria
Qualifiers
scheduled for cardiac surgery (aortic valve replacement, coronary artery bypass graft, mitral valve repair or replacement, intracardiac tumor, aortic root repair)
under cardiopulmonary bypass
Affiliation to the French national healthcare system
Written consent obtained
Disqualifiers
age<18
weight<50 kg
chronic use of NSAID
mini-invasive surgery
Trial design
Treatments tested in this trial
- pain management
- ketoprofen
- PLacebo
Treatment groups
Sponsors and collaborators
Centre Hospitalier Universitaire, Amiens
Lead sponsor
University Hospital, Rouen
Collaborator
University Hospital, Lille
Collaborator
University Hospital, Caen
Collaborator