Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age45+
SponsorJagiellonian University
About this trial
The effect of noradrenaline infusion versus standard blood pressure management on perioperative HYPotension in NOn-caRdiac surgery.
The study aims to determine whether perioperative noradrenaline infusion is superior to standard blood pressure management for the occurrence of perioperative hypotension.
Eligibility criteria
Qualifiers
≥45 years old
Elective or accelerated* non-cardiac surgery expected to last ≥1 hour and requiring general, neuraxial, or combined general with neuraxial anesthesia
Expected to stay overnight in the hospital after surgery
Written informed consent to participate in the HYP-NOR Trial provided
Disqualifiers
Newly diagnosed, untreated, or uncontrolled hypertension -in two measurements on the day before surgery Systolic Blood Pressure (SBP) ≥180 mm Hg or Diastolic Blood Pressure (DBP) ≥110 mm Hg
Persistent difference in recorded SBP between right and left upper limb >10 mm Hg
Persistent atrial fibrillation
Have a documented history of dementia
Trial design
Treatments tested in this trial
- noradrenaline infusion for management blood pressure
- standard blood pressure management
Treatment groups
750 Participants
are divided into 2 treatment groupsSponsors and collaborators
Jagiellonian University
Lead sponsor
Medical Research Agency, Poland
Collaborator
Source ClinicalTrials.gov