Post-Op Pain Control for Prophylactic Intramedullary Nailing.

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorSt. Louis University

About this trial

Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing and nonunion due to NSAID use. Orthopedic oncology, however, has a unique subset of patients that undergo prophylactic placement of intramedullary femoral nails. Because no fracture is present, these patients do not rely on inflammatory healing factors, allowing for post-op NSAID use. This study sets out to determine the effect of post-op toradol use in addition to opioids compared to solely opioids in patients undergoing prophylactic nailing of the femur.

Eligibility criteria

Qualifiers

Femoral Shaft or Neck bone lesion

18 years old or greater

Plan to undergo prophylactic intramedullary nailing of one femur

Disqualifiers

Concurrent pathologic fracture

History of advanced renal impairment (eGFR<30mL/min)

History of Peptic Ulcer Disease with bleeding or requiring hospitalization

History of NSAID or aspirin allergy

Trial design

Treatments tested in this trial

  • Ketorolac
  • Normal saline
  • Acetaminophen
  • Oxycodone Acetaminophen
  • Morphine
  • Hydrocodone/Acetaminophen
  • Oxycodone

Treatment groups

60 Participants
are divided into 2 treatment groups

Sponsors and collaborators