To determine if prophylactic administration of amiodarone for 72 hours in critically ill patients admitted after an OHCA with shockable rhythm, with a confirmed or a presumed cardiac cause, decreases the incidence of a composite endpoint of 30-day (starting from inclusion) all-cause mortality and/or severe in-hospital ventricular arrhythmia recurrence (ventricular fibrillation and/or ventricular tachycardia requiring intervention including re-arrest)
Patient aged ≥ 18 years
Admitted in intensive care unit
Out-of-hospital cardiac arrest with initial shockable rhythm
Presumed cardiac or unknown cause
Cardiac arrest secondary to an extra-cardiac cause (suspected or confirmed)
Indication for amiodarone decided by the physician at ICU admission
No central venous catheter available for continuous infusion of amidoarone
Thyroid disease under treatment