Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Texas Southwestern Medical Center

About this trial

The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7), and one using an admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2), for anesthesia during endoscopic procedures at the Clements University Hospital (CUH) endoscopy lab (Endo).

Eligibility criteria

Qualifiers

Adult patients (age ≥18 years old)

Having endoscopic procedure at CUH with anesthesia

ASA 3 or above

Ejection Fraction test result available

Disqualifiers

Known allergies or adverse reactions to study drugs or study drug components or preservatives

Patient refusal

Clinician refusal

Documented cognitive impairments precluding subject ability to consent for themselves unless a surrogate documented legally acceptable decision maker consents for patient participation

Trial design

Treatments tested in this trial

  • Admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2)
  • Admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7)

Treatment groups

200 Participants
are divided into 2 treatment groups