Randomised Evaluation of COVID-19 Therapy
ConditionPneumonia
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age0+
SponsorUniversity of Oxford
About this trial
RECOVERY is a randomised trial of treatments to prevent death in patients hospitalised with pneumonia.
The treatments being investigated are:
COVID-19: Lopinavir-Ritonavir, Hydroxychloroquine, Corticosteroids, Azithromycin, Colchicine, IV Immunoglobulin (children only), Convalescent plasma, Casirivimab+Imdevimab, Tocilizumab, Aspirin, Baricitinib, Empagliflozin, Sotrovimab, Molnupiravir, Paxlovid or Anakinra (children only)
Influenza: Baloxavir marboxil, Oseltamivir, Corticosteroids (dexamethasone)
Community-acquired pneumonia: Corticosteroids (dexamethasone)
Eligibility criteria
Qualifiers
typical symptoms of a new respiratory tract infection (e.g. influenza-like illness with fever and muscle pain, or respiratory illness with cough and shortness of breath); and
objective evidence of acute lung disease (e.g. consolidation or ground-glass shadowing on X-ray or CT, hypoxia, or compatible clinical examination); and
alternative causes have been considered unlikely or excluded (e.g. heart failure).
Confirmed influenza A or B infection (including patients with SARS-CoV-2 co-infection)
Disqualifiers
None
Trial design
Treatments tested in this trial
- Lopinavir-Ritonavir
- Corticosteroid
- Hydroxychloroquine
- Azithromycin
- Convalescent plasma
- Tocilizumab
- Immunoglobulin
- Synthetic neutralising antibodies
- Aspirin
- Colchicine
- Baricitinib
- Anakinra
- Dimethyl fumarate
- High Dose Corticosteroid
- Empagliflozin
- Sotrovimab
- Molnupiravir
- Paxlovid
- Baloxavir Marboxil
- Oseltamivir
- Corticosteroids (dexamethasone)
- Corticosteroids (dexamethasone)
Treatment groups
70,000 Participants
are divided into 23 treatment groups23
Treatment groupsSee each treatment group below.
Sponsors and collaborators
University of Oxford
Lead sponsor
UK Research and Innovation
Collaborator
National Institute for Health Research, United Kingdom
Collaborator
Wellcome Trust
Collaborator
Bill and Melinda Gates Foundation
Collaborator
Department for International Development, United Kingdom
Collaborator
Health Data Research UK
Collaborator
Medical Research Council Population Health Research Unit
Collaborator
NIHR Health Protection Research Unit in Emerging and Zoonotic Infections
Collaborator
Flu Lab
Collaborator
Source ClinicalTrials.gov