Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis

ConditionPost-ERCP Acute Pancreatitis

Trial statusRecruiting

Trial phasePhase 3

Trial typeInterventional

Biological sexAll

Age18+

SponsorJohns Hopkins University

About this trial

This research is being done to see if using oral tacrolimus before endoscopy, can prevent pancreatitis that may occur after ERCP (a type of gastrointestinal endoscopy).

Eligibility criteria

Qualifiers

Any patient who is undergoing endoscopic retrograde cholangiopancreatography (ERCP) at any of the participating centers, is at least 18 years old and provides informed consent can be included in the study.

Disqualifiers

Unwillingness or inability to consent for the study.

Pregnancy

Breastfeeding mother

Chronic calcific pancreatitis

Trial design

Treatments tested in this trial

Tacrolimus capsule
Placebo
Rectal Indomethacin

Treatment groups

4,874 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Johns Hopkins University

Lead sponsor

Source ClinicalTrials.gov