Reducing Cardiac-surgery Associated Acute Kidney Injury Occurence by Administering Angiotensin II

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversität Münster

About this trial

The study intervention focuses on exploring the use of angiotensin II as a primary vasopressor compared to norepinephrine in cardiac surgery patients to investigate whether angiotensin II can reduce the occurrence of moderate/severe acute kidney injury (AKI). Despite its potential, as suggested by trials involving surgical patients, there is currently no human data confirming its effectiveness in preventing moderate/severe AKI in this context. The intervention aims to address this gap by evaluating angiotensin II's impact compared to norepinephrine.

Eligibility criteria

Qualifiers

Cardiac surgery using cardiopulmonary bypass including coronary artery bypass grafting (CABG) surgery, valve surgery, or combined CABG/valve surgery

hemoglobin < 130g/l = 2

creatinine > 1.1 mg/dl = 2

age > 70 years =1.5

Disqualifiers

Major aortic surgery (aortic arch replacement), transplant surgery, pulmonary thrombendarterectomy, ventricular assist device placement

Already receiving inotropic/vasopressor support before surgery

Dialysis dependent

Pre-existing AKI within the last 30 days

Trial design

Treatments tested in this trial

  • Angiotensin II
  • Noradrenalin

Treatment groups

1,022 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Universität Münster

Lead sponsor

German Research Foundation

Collaborator