About this trial
The study intervention focuses on exploring the use of angiotensin II as a primary vasopressor compared to norepinephrine in cardiac surgery patients to investigate whether angiotensin II can reduce the occurrence of moderate/severe acute kidney injury (AKI). Despite its potential, as suggested by trials involving surgical patients, there is currently no human data confirming its effectiveness in preventing moderate/severe AKI in this context. The intervention aims to address this gap by evaluating angiotensin II's impact compared to norepinephrine.
Eligibility criteria
Qualifiers
Cardiac surgery using cardiopulmonary bypass including coronary artery bypass grafting (CABG) surgery, valve surgery, or combined CABG/valve surgery
hemoglobin < 130g/l = 2
creatinine > 1.1 mg/dl = 2
age > 70 years =1.5
Disqualifiers
Major aortic surgery (aortic arch replacement), transplant surgery, pulmonary thrombendarterectomy, ventricular assist device placement
Already receiving inotropic/vasopressor support before surgery
Dialysis dependent
Pre-existing AKI within the last 30 days
Trial design
Treatments tested in this trial
- Angiotensin II
- Noradrenalin
Treatment groups
Sponsors and collaborators
Universität Münster
Lead sponsor
German Research Foundation
Collaborator