Safest Choice of Antihypertensive Regimen for Postpartum Hypertension
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexFemale
Age18+
SponsorLoma Linda University
About this trial
The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.
Eligibility criteria
Qualifiers
Female
Women who develop postpartum hypertension* after delivery of the placenta or chronic hypertensive postpartum women who require medication for blood pressure control.
Postpartum hypertension requiring treatment are defined as systolic blood pressure greater than or equal to 140mmHg or diastolic blood pressure greater than or equal to 90mmHg on at least 2 occasions at least 4 hours apart, or systolic blood pressure greater than or equal to 160mmHg or diastolic blood pressure greater than 110mmHg sustained for more than 15 minutes.
Disqualifiers
History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema
Contraindication to either Nifedipine or Labetalol
HR <60 or >110
Native language other than English or Spanish
Trial design
Treatments tested in this trial
- Oral Nifedipine
- Oral Labetalol
Treatment groups
500 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov