Study of Comparing of With and Without Sequential Therapy of S-1
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18-75
SponsorZhejiang University
About this trial
The goal of this single arm clinical trial is to learn about sequential S-1 adjuvant therapy in patient wich locally advanced gastric cancer. The main question it aims to answer is:
• The efficacy and safety of S-1 adjuvant therapy, following D2 radical surgery and DS(Docetaxel + S-1) adjuvant chemotherapy.
All patients with locally advanced gastric cancer will received D2 radical surgery, 6 cycles of DS chemotherapy, and sequential S-1 chemotherapy up to 1 year postoperation.
Eligibility criteria
Qualifiers
(1) Histologically or cytologically confirmed adenocarcinoma of the stomach or adenocarcinoma of the gastroesophageal junction;
(2) Radical surgery (D2 lymph node dissection) for gastric cancer in our center, with postoperative pathological stage of stage III;
(3) No significant tumor recurrence or metastasis as assessed by imaging;
(4) Age 18 years - 75 years;
Disqualifiers
(1) Other pathological types of tumors;
(2) Pregnant or nursing women;
(3) Those with a history of other malignant neoplastic disease in the last 5 years;
(4) Those with a history of uncontrolled epilepsy, central nervous system disease, or psychiatric disorder, where the investigator determines whether the clinical severity prevents signing an informed consent form or affects the patient's compliance with oral medications;
Trial design
Treatments tested in this trial
- Docetaxel
- Tegafur-Gimeracil-Oteracil
Treatment groups
70 Participants
are divided into 1 treatment groupLocations
1Map coordinates are unavailable for these locations. Locations are shown below instead.
Gastrointestinal Department of Second Affiliated Hospital of Zhejiang UniversityRecruiting310000, Hanzhou, Zhejiang
China
ChinaSponsors and collaborators
Source ClinicalTrials.gov