Surufatinib Plus Gemcitabine and Nab-paclitaxel vs. Gemcitabine Plus Nab-paclitaxel in Neoadjuvant Therapy for High - Risk Resectable or Borderline Resectable Pancreatic Cancer

Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18-75
SponsorTianjin Medical University Cancer Institute and Hospital

About this trial

To explore the efficacy and safety of surufatinib in combination with AG regimen verus AG regimen as peri-operative treatment in high - risk resectable or borderline resectable pancreatic cancer

Eligibility criteria

Qualifiers

Histologically or cytologically confirmed high-risk resectable or borderline resectable pancreatic cancer;

18-75 years old (including 18 and 75 years old);

No BRCA1/2 or PALB2 mutation;

No previous pancreatic cancer resection, systemic therapy, or local radiation therapy;

Disqualifiers

With distant metastasis;

Have received blood transfusion treatment, blood products and hematopoietic factors, such as albumin and granulocyte colony-stimulating factor (G-CSF) within 14 days before enrollment;

Have received any surgery or invasive treatment or operation within 4 weeks before enrollment (except venous catheterization, puncture and drainage, etc.);

Allergic to the study drug or any of its adjuvants;

Trial design

Treatments tested in this trial

  • surufatinib + gemcitabine + nab-paclitaxel
  • gemcitabine + nab-paclitaxel

Treatment groups

106 Participants
are divided into 2 treatment groups