Systemic Treatment Alone Versus Systemic Treatment Plus Radiotherapy in Oligometastatic Renal Cell Carcinoma

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age20-80
SponsorSamsung Medical Center

About this trial

To evaluate whether incorporating locoregional radiotherapy in the treatment of oligometastatic renal cell carcinoma, including inductive oligometastases, along with standard systemic therapy, contributes to improved progression-free survival rates for patients.

Eligibility criteria

Qualifiers

Patients with metastatic renal cell carcinoma classified within the ESTRO/EORTC classification system as having ≤ 5 metastases, ≤ 3 metastatic organs, and meeting criteria for new, recurrent, or induced metastases.

Patients aged 20 to 80 years.

Patients with individual metastases ≤ 5 cm in longest diameter.

Patients with primary tumors surgically removed or scheduled for surgery.

Disqualifiers

Patients with total bilirubin > 3.6 mg/dL.

Patients with AST >160 U/L, ALT > 165 U/L.

Patients unable to maintain position for partial nephrectomy radiotherapy.

Patients with a history of radiotherapy to metastatic renal cell carcinoma or surrounding areas.

Trial design

Treatments tested in this trial

  • SBRT(Stereotatic Body Radiation Therapy)

Treatment groups

88 Participants
are divided into 2 treatment groups

Sponsors and collaborators