The Direct Oral Anticoagulation Versus Vitamin K Antagonist After Cardiac Surgery Trial
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorPopulation Health Research Institute
About this trial
The DANCE Trial is a multi-centre, randomized controlled trial comparing the safety of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) in the early period (30 days) after cardiac surgery in patients with atrial fibrillation requiring oral anticoagulation.
Eligibility criteria
Qualifiers
Age ≥18 years at the time of enrolment,
Open heart surgery in the last 10 days,
Atrial fibrillation requiring anticoagulation (including pre-existing or post-operative atrial fibrillation),
Informed consent from either the patient or a substitute decision-maker.
Disqualifiers
Mechanical valve replacement,
Antiphospholipid syndrome (triple positive),
Severe renal failure (Cockcroft-Gault equation; creatinine clearance <15 ml/min),
Known significant liver disease (Child-Pugh classification B and C),
Trial design
Treatments tested in this trial
- DOAC
- VKA
Treatment groups
3,500 Participants
are divided into 2 treatment groupsSponsors and collaborators
Population Health Research Institute
Lead sponsor
Hamilton Health Sciences Corporation
Collaborator
Source ClinicalTrials.gov