The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery

ConditionsMyocardium; Injury Perioperative/Postoperative Complications Angiotensin-Converting-Enzyme Inhibitor

Trial statusRecruiting

Trial phasePhase 3

Trial typeInterventional

Biological sexAll

Age18-70

SponsorKasr El Aini Hospital

About this trial

The aim of this study is to estimate the effect of discontinuation of RAS inhibitors on myocardial injury in cancer patients undergoing major abdominal surgeries.

Eligibility criteria

Qualifiers

Age > 18 years

Both sexes

ASA 2-3

Chronic hypertensive patients (> 3 months before surgery) controlled on ACEIs or ARBs or combination therapy containing one of the RAS inhibitors.

Disqualifiers

Patient refusal.

Recent myocardial infarction (within 3 months).

Any condition, which in the opinion of the treating clinician, would result in the patient being harmed by the cessation of the ACE-I and/or ARB therapy.

Emergency surgery

Trial design

Treatments tested in this trial

ACE-I and/or ARB antihypertensive treatment

Treatment groups

156 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Kasr El Aini Hospital

Lead sponsor

Source ClinicalTrials.gov