The purpose of this study is to evaluate the safety, feasibility and outcomes of neoadjuvant chemotherapy followed by esophagectomy versus neoadjuvant chemoradiotherapy followed by esophagectomy for locally advanced resectable esophageal squamous cell carcinoma cT3-4aN0M0, cT1-4aN1-3M0. This is non-inferiority study (neoadjuvant chemoradiotherapy has no advantage over neoadjuvant chemotherapy).
Written informed consent.
Histologically confirmed squamous cell carcinoma of the esophagus.
Clinical stage cT1-4aN1-3M0 (AJCC/UICC 8th Edition).
Indications for surgical esophageal resection
Clinical stage cT4bcN0cM0 (AJCC/UICC 8th Edition).
Patients with advanced non-operable or metastatic esophageal cancer.
Patients who have received or are receiving other chemotherapy, radiotherapy or targeted therapy.
Patients with another previous or current malignant disease.