XePOHCAS: Prospective, randomized, multicenter interventional trial in adult subjects with out-of-hospital cardiac arrest comparing treatment with standard-of-care post-cardiac arrest intensive care (which is targeted temperature management \[TTM\]) to xenon by inhalation plus standard-of-care post-cardiac arrest intensive care (including TTM).
Age at least 18 years but less than or equal to 80 years
Presumed cardiac cause of arrest
Sustained (>20 minutes) spontaneous circulation upon arrival in the emergency department
No response to verbal commands on arrival to emergency department and prior to randomization (Glasgow Coma Scale score of <8)
Written do not attempt resuscitation reported to providers before randomization
Traumatic etiology of arrest, defined as concomitant blunt, penetrating, or burn-related injury, or uncontrolled bleeding or exsanguination
Suspected or known stroke or intracranial hemorrhage
Unwitnessed cardiac arrest