A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation
ConditionTotal Knee Replacement
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age50-85
SponsorChristian Candrian
About this trial
We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols. We'll evaluate the outcome of patients with knee osteoarthritis who are undergoing Total Knee Arthroplasty to understand which of the three treatments give more benefits to the patient.
Eligibility criteria
Qualifiers
Patients undergoing unilateral primary TKA at the Ospedale Regionale di Lugano.
Patients with a BMI >18.5 and <35.
Patients able to provide informed consent and follow all the study procedures as indicated by the protocol.
Informed Consent as documented by signature (Appendix Informed Consent Form).
Disqualifiers
Contraindications to steroids.
Revision TKA.
Active steroid therapy.
Women who are pregnant or breast feeding.
Trial design
Treatments tested in this trial
- Dexamethasone Sodium Phosphate 4 mg/ml intravenous
- Dexamethasone Sodium Phosphate 4 mg/ml intra-articular
Treatment groups
159 Participants
are divided into 3 treatment groupsSponsors and collaborators
Christian Candrian
Lead sponsor
Ente Ospedaliero Cantonale, Bellinzona
Sponsor institution
Source ClinicalTrials.gov