The main purpose of this study is to evaluate the efficacy of ocrelizumab in participants with relapsing multiple sclerosis (RMS) and to characterize the ocrelizumab pharmacodynamic (PD) profile in Chinese participants with primary progressive multiple sclerosis (PPMS).
Diagnosis of RMS/PPMS in accordance with the revised 2017 McDonald Criteria
EDSS score from 0-5.5 (RMS) or 3.0-6.5 (PPMS), inclusive, at screening and baseline
Documented MRI of brain with abnormalities consistent with MS before screening
Diagnosis of PPMS or non-active secondary progressive multiple sclerosis (SPMS) (only for RMS cohort)
History of relapsing remitting multiple sclerosis (RRMS) or SPMS at screening (only for PPMS cohort)
Disease duration of more than 10 years in participants with an EDSS ≤ 2.0 at screening (only for RMS cohort)
History of confirmed or suspected progressive multifocal leukoencephalopathy (PML)