Access to Hepatitis C Treatment in Cameroon: Comparison of a Simplified Test and Treat Strategy to a Standard Strategy

Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age21+
SponsorANRS, Emerging Infectious Diseases

About this trial

Hepatitis C is a common and potentially serious disease. However, there are treatments that can cure it. That's why it's so important to detect the hepatitis C virus (HCV) and treat those affected. Today, many hepatitis C sufferers in Cameroon (and elsewhere) remain untreated.

The aim of this research is therefore to evaluate a simplified screening and treatment strategy (developed specifically for the Cameroonian context) in comparison with a standard strategy (based on usual care), in order to improve access to hepatitis C treatment in Cameroon. If the results of this research are positive, this strategy could be recommended to health authorities in Cameroon and other comparable countries.

Eligibility criteria

Qualifiers

Persons of both genders aged 21 years or older

Anti-HCV positive;

Living in the study area

Agreeing to participate in the trial and signing the informed consent form.

Disqualifiers

Participationin a previous study on HCV treatment

Previous sofosbuvir treatment

HBsAg positive or indeterminate;

Pregnancy test positive ;

Trial design

Treatments tested in this trial

  • ACCESS+ strategy Epclusa 400/100 Oral Tablet
  • ACCESS+ Strategy Vosevi 400/100/100 Oral Tablet
  • Standard Strategy Vosevi 400/100/100 Oral Tablet
  • Standard Strategy Epclusa 400/100 Oral Tablet

Treatment groups

576 Participants
are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

ANRS, Emerging Infectious Diseases

Lead sponsor

IRD, Epidemiologie et Prevention, Montpelier, France

Collaborator

SESSTIM (IRD, Inserm, Université Aix-Marseille)

Collaborator

Centre de Recherche sur les Maladies Emergentes et Re-Emergentes (CREMER)

Collaborator

Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé I, Yaoundé, Cameroun

Collaborator

PharmAccess

Collaborator

Service d'hépato-gastroentérologie, Hôpital Saint Joseph, Marseille, France

Collaborator